Guideline for FCPS Part 1 Pathology


Pathology Guidelines..
The biggest question we all face while preparing for Part 1 is that do we have to do general and special pathology both??
The answer is! If you go by the rules, then only the general pathology shall be done.

however if you don’t go by the rules as I hope there aren’t any rules for FCPS-1 then you shall do some important topics of special pathology too that are absolutely well covered by the first aid (the golden book for the part 1) I have compiled certain topics from patho as a whole that are frequently asked in the paper, please remember every detail of these. For my fellows appearing in surgery and medicine please bear in mind pathology is asked so much in paper 2 that damagh seedha ho jata he !


Recommended books: General Patho; BRS

Special patho;  first Aid


General pathology..

    • Effect of vitamin A on metaplasia
    • Cellular changes typical of reversible and irreversible cell damage, CPSP has got love for this topic believes me learn this by heart.
    • Nuclear changes in cell death.
    • Genes regulating apoptosis (bCL-2, p-53, capsases and a few others), they are seen showing up in the mcqs very frequently now.
    • Clear concepts of anaplasia, metaplasia and dysplasia as they twist the definition in a very tricky way and sometimes it’s very difficult to get the point even though it seems simple!
    • Antioxidants, and their efficacy levels, like which is superior to whom!
    • Granules of neutrophils and platelets and their contents.
    • CRYSTAL clear concept of histamine, serotonin and bradykinin shall be there.
    • Cells of chronic inflammation and types of granulomas.
    • Disorders of primary hemostasis like VWB disease, Bernard soulier and Glans man thrombasthenia. The details shall be on figure tips that the disorders pertain to defects in adhesion or platelet plug progression etc.

  • Again an important topic, differences between extrinsic and intrinsic pathways.
    Lab tests used to monitor extrinsic and intrinsic pathways.
    Different coagulation factors in intrinsic and extrinsic pathways.
    Mode of action of heparin and LMW heparins. Mode of action of warfarin and the factors it targets. ANTIDOTES of heparin, warfarin, t-PA and streptokinase.
  • Coagulation factors that are dependent on vitamin k, time duration before aspirin and clopidogrel shall be stopped before surgery.
  • Different types of Shock and their pathophysiologies.
  • Hemophilia and its mode of inheritance
  • OK now we come to an absolute necessary entity of the paper; Autosomal dominant, Recessive play ;p O God I don’t know from where they invent strange and funny diseases and ask their inheritance patterns so dear folks let’s see where we can muster up all that’s necessary to bat their questions, the reward lies in the first aid biochem section. Please read that very clearly and spend a good amount of time on that, make some mnemonics and remember the mode of inheritance of all possible diseases.
    Some times more than one mcqs from those is asked!
  • Among Genetic disorders! Downs, Edward and Patau.
  • Tumor markers and carcinogens. Viruses and chemicals; a must do!
  • All vitamins and the pathologies they cause. All means ALL!
  • Differences between kawashiorkar and marasmus.




  • Only thing that needs to be in detail without leaving any topic is BLOOD.

Believe me this blood is a bloody thing, sometimes showing up to 8 MCQS in the paper, means it can implicit whether one passes or fails!!
I think this intro is sufficient. Among the topics of blood numeric values of translocations of ALL leukemias shall be on the figure tips!
Different types of cells shall be remembered like bite cells, Heinz bodies, foam cells, schistocytes, helmet cells, target cells.
Please do all topics of blood in detail.

  • Nephron section, ultra structural and fluorescent changes in different glomerulonephropathies.
  • Kidney stones and RCC.
  • ADPKD and its manifestations.
  • GIT section, stomach tumors, general overview only. Ulcerative colitis and crohns
    all-time favorites, ischemic bowel disease, mackle’s with the rule of 2%, polyps in full detail, causes of pre and post hepatic jaundice including all the syndromes and primary sclerosing cholangitis plus PBC.
    Mutations of Colorectal carcinoma.
  • CNS, all hemorrhages, CNS tumors and their morphologies.
    Meningitis, most common organisms and the differences in their lab results.
  • Breast and female genetilia, Paget’s disease, organisms of mastitis, fibro adenoma and only slight knowledge of breast tumors is tested.

Ovarian tumors and their tumor markers. Concentrate on epithelial tumors more and general idea of germ cell and sex cord tumors.

  • Male genetilia, morphologies and tumor markers of testicular tumors.
  • Bones and joints, bone tumors and their sites on bone, as in metaphysis or diaphysis; again a mandatory MCQ. Osteomyelitis and organisms responsible.
  • Vascular and cardiac pathology, all vasculitidies! Mandatory!

Changes in heart after MI with pertinence to time and similarly complications occurring at those specific times. Rheumatic fever, its pathology and morphology of lesion.

Infective endocarditis and the responsible organisms!  A mandatory MCQ.

Remember details about acute, sub-acute and prosthetic valve endocarditis,
endocarditis in IV abusers.

  • Respiratory section, lung tumors and their locations

Para neoplastic syndromes associated, remember SCC and Small cell carcinoma have different paraneoplastics and that is what is being tested again and again.

Differences between different types of emphysema,
pneumonia, different types and organisms in different ages.


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